Immune mechanisms driving the acquisition of remission following treatment with Probiotic and Peanut Oral Immunotherapy (PPOIT)

Prof. Mimi Tang, Group Leader, Allergy Immunology, Murdoch Children’s Research Institute, Australia
2022

Food allergies are a major health burden globally1. There iscurrently no cure so management relies on allergen avoidance, which causessignificantly reduced quality of life. Progress has been hampered by a limitedunderstanding of the immune mechanisms that drive the transition from allergyto remission. Oral immunotherapy (OIT) shows promise but has major drawbacks. Treatmentsthat induce lasting remission with fewer side effects are needed.

 

Study Aim

To investigate immune changes that underpin long-lastingremission from a treatment that combines a probiotic adjuvant alongside OIT(Probiotic Peanut OIT; PPOIT).

 

Scientific Approach

Long term follow-up mechanistic investigations from probioticpeanut oral immunotherapy (PPOIT) cohort.

 

Expected Outcomes

The findings of this study will provide invaluable insightson longer term effects following probiotic peanut oral immunotherapy treatment,and on the immune mechanisms underpinning the desired long-lasting remission,and therefore will pave the way for probiotic solutions as an adjunct to oralimmunotherapy.

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