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Atopic dermatitis (AD) is one of the most common inflammatory skin diseases in infants, but its causes are still not fully understood. Increasing research suggests that the developing gut microbiota—especially bacteria that produce the beneficial metabolite butyrate—may play an important role in shaping early immune function. Yet,little is known about how these bacteria establish during the first year of life or whether their early presence influences a child’s risk of developing AD.
Study Aim
This study aims to determine whether the early colonization of butyrate-producing bacteria is linked to the likelihood of developing atopic dermatitis during infancy.
Scientific Approach
Fecal samples collected from the infants of the CARE birth cohort at 3, 6,12 and 24 months of age will be analysed. Data obtained will be linked to fecal SCFA profiles of the infants, diet and environmental parameters.
By comparing infants who develop AD with those who remain healthy, the study will identify microbial and metabolic differences that may influence disease risk.
Expected Outcomes
This research has the potential to deepen our understanding of the gut microbiome – atopic dermatitis connection and uncover new opportunities to improve infant health through early microbial support.
