Atopic Dermatitis (AD) is the earliest and the most commonmanifestation of allergies. Recent studies have shown that allergies wereassociated with a disruption of the gut microbial ‘balance’ suggesting that theuse of nutritional intervention very early in life may restore an optimalpattern of microflora aiming at improving the host’s health.
Study Aim
So far, most human intervention studies have focused onimproving postnatal infant colonization. The clinical trial PREGRALL will bethe first to test the hypothesis that a maternal antenatal prebiotics(GOS/inulin) supplementation will prevent AD in high-risk children.
Scientific Approach
Randomised clinical study with allergic pregnant womenreceiving prebiotics supplementation or placebo, from 20 weeks of pregnancy todelivery. Primary outcome is AD prevalence at one year old.
Expected Outcomes
This clinical trial’s outcomes will provide evidence that prebiotics could modify favourably the placental microbiota which could impact then on fœtus immune system orientation to protect against allergies.
