Diet remains one of the main drivers of obesity pandemic, inparticular the overconsumption of calorically-dense palatable foods in earlylife. There is increasing interesting to further our understanding of thepathways in the brain that drive excess unhealthy food consumption and how theyare established from the onset.
Study Aim
To investigate the role of the early-life diet-microbiotaaxis on the establishment of healthy eating behavior in adulthood usingrelevant preclinical models; and to examine the potential ofgut-microbiota-based interventions in remediating such effects.
Scientific Approach
The research proposal will explore the mechanisms underlyingdiet-mediated metabolic imprinting and neuronal development of food rewardsignaling in the brain in early life, and how they drive eating behavior, byusing preclinical models.
Expected Outcomes
